Well, two.

Up on the top bar, why is "manage friends" so close to "flag journal"? A couple of times I have started to create a friendslist and nearly ended up reporting someone's journal to LJ by mistake--not very friendly!

Likewise, when you mouse over someone's userpic and get that little list of options, they are all so close together that one day I am sure to "Remove Friend" when all I wanted to do was go to their journal.

I apologize in advance if I pull either of those on you.